The two-volume set LNCS 12385 + 12386 constitutes the proceedings of the 15th International Conference on Wireless Algorithms, Systems, and Applications, WASA 2020, which was held during September 13-15, 2020. The conference was planned to take place in Qingdao, China; due to the COVID-19 pandemic it was held virtually. The 67 full and 14 short papers presented in these proceedings were carefully reviewed and selected from 216 submissions. These submissions cover many hot research topics, including machine-learning algorithms for wireless systems and applications, Internet of Things (IoTs) and related wireless solutions, wireless networking for cyber-physical systems (CPSs), security and privacy solutions for wireless applications, blockchain solutions for mobile applications, mobile edge computing, wireless sensor networks, distributed and localized algorithm design and analysis, wireless crowdsourcing, mobile cloud computing, vehicular networks, wireless solutions for smart cities, wireless algorithms for smart grids, mobile social networks, mobile system security, storage systems for mobile applications, etc.