Asynchronous circuits provide efficient solutions for many of the recent nanometric technologies, although the lack of analysis and optimization tools has limited the commercial spread of this technology. This book helps readers to understand the difficulties of modeling and analyzing asynchronous circuits. A new modeling methodology is introduced; it is used to build Asynchronous Static Timing Analysis (ASTA) and Asynchronous Statistical Static Timing Analysis (ASSTA). These fast and accurate methods are used to optimize the circuit speed against its hardware size. In addition, the book investigates the handshaking protocol effect on different asynchronous circuit performance metrics (speed, power consumption, EMI and robustness against process variability). The book is accompanied by AHMOSE (Asynchronous High-speed Modeling and Optimization Tool-set), a demonstrative software, which provides to the user a better understanding and usage of the explained methods.