This book contains the contributions presented at the 8th International KES Conference on Smart Education and e-Learning (KES SEEL 2021), which being held as a virtual conference on June 14–16, 2021. It contains high-quality peer-reviewed papers that are grouped into several interconnected parts: smart education; smart e-learning; smart education: systems and technology; smart education: case studies and research; digital education and economics in smart university, smart university development: organizational, managerial and social Issues; smart universities and their Impact on students with disabilities. This book serves as a useful source of research data and valuable information on current research projects, best practices, and case studies for faculty, scholars, Ph.D. students, administrators, and practitioners— all those who are interested in smart education and smart e-learning.