Malignant glioma is generally considered one of the most therapeutically difficult cerebral tumors. This book deals with many aspects of gliomas, including factors related to incidence and epidemiology, and surveys the history of glioma therapies. Experimental studies carried out by the Sendai Group of Neurosurgeons are reported, together with the results of many clinical studies of RAFP therapy. This particular theorapy involves the administration of radiation treatment and three chemical compounds: ACNU, Futraful and PSK. A recent technique for evaluating the effectiveness of therapy based on MRI diagnostic methods is introduced. This book thus offers valuable information and guidelines for future developments in treatment.