This book presents emerging trends in intelligent computing and informatics. This book presents the papers included in the proceedings of the 6th International Conference of Reliable Information and Communication Technology 2021 (IRICT 2021) that was held virtually, on Dec. 22-23, 2021. The main theme of the book is “Advances on Intelligent Informatics and Computing”. A total of 87 papers were submitted to the conference, but only 66 papers were accepted and published in this book. The book presents several hot research topics which include health informatics, artificial intelligence, soft computing, data science, big data analytics, Internet of Things (IoT), intelligent communication systems, cybersecurity, and information systems.