This volume comprises the select proceedings of the 2nd International Conference on Signal & Data Processing (ICSDP) 2022. The contents focus on the latest research and developments in the field of artificial intelligence & machine learning, Internet of things (IoT), cybernetics, advanced communication systems, VLSI embedded systems, power electronics and automation, MEMS/ nanotechnology, renewable energy, bioinformatics, data acquisition and mining, antenna & RF systems, power systems, biomedical engineering, aerospace & navigation. This volume will prove to be a valuable resource for those in academia and industry.