This book explores the effects of covid-19 crisis on cities and urban areas and proposes approaches and solutions to invert the pandemic's negative impact. The covid-19 crisis has had significant impacts on public health, on the everyday lives of millions of people, and on the use of urban spaces at all levels. All over the world, cities have been at the forefront of a crisis that have worsened socio-spatial inequalities between regions and inside urban areas. The book examines three aspects of the connection between pandemic and urban issues: the relevance of spatial and territorial variables in the explanation of pandemic dynamics and consequences in fragile cities; the assumption of radical uncertainty as the conceptual framework for a new approach to urban planning, in a phase of raise of public investments; and the design of urban policies aimed at facing the material and symbolic effects of pandemic on the practices of use of spaces and places, in a context characterized by a plurality of populations and forms of life.