This volume forms part of a prestigious series and covers the latest advances in our understanding of the pathophysiology and treatment of asthma. Our understanding of asthma has changed dramatically in recent years, and much of this new information is brought together in this volume written by inter­ nationally recognised authorities. The aim of the book is to review in depth the changing concepts of inflammatory processes in asthma and to discuss the implications for research of this common chronic disease. Many of the advances in and future therapy our understanding of asthma have originated from a pharmacological approach, and this volume highlights the promising new options for pharma­ cological intervention. It is hoped this book will be invaluable for research scientists and clinic­ ians involved in asthma research and will be a major reference resource for chest physicians and those involved in the development of novel pharmaceu­ tical entities. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this growing area. c.P. PAGE P.l. BARNES Contents CHAPTER 1 The Pathology of Asthma: An Overview L.A. LAmNEN and A. LAmNEN. With 10 Figures ...................... 1 A. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . 1 . . . . . . . . . . . . . . . B. Methods to Investigate the Pathology of Human Asthma ............ 1 C. Bronchial Epithelium and Inflammatory Cells in Asthmatic Patients Between Attacks ........................... 2 I. Mast Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . 4 . . . . . . . . . . . . . . II. Eosinophils ............................................... 7 III.Neutrophils.............................................. 10 D. Bronchial Epithelial Inflammation During an Asthma Attack. . . . . .. . 10 E. Epithelial Regeneration .... . . . . . . . . . . . . . . . . . . . . . . .. . . 12 . . . . . . . . .

Contributions by: A.G. Alexander, P.J. Barnes, K.F. Chung, R.J. Flower, L.G. Garland, R.G. Goldie, S.T. Holgate, A.B. Kay, A. Laitinen, L.A. Laitinen, K.M. Lulich, C.P. Page, J.W. Paterson, R. Pauwels, C.G.A. Persson, I.W. Rodger, M. Schmitz-Schumann, R.C. Small, S.F. Smith, A. Szczeklik, C. Virchow, J.W. Wilson