DCAI 2022 is a forum to present applications of innovative techniques for studying and solving complex problems in artificial intelligence and computing areas. The present edition brings together past experience, current work and promising future trends associated with distributed computing, artificial intelligence and their application in order to provide efficient solutions to real problems. This year’s technical program will present both high quality and diversity, with contributions in well-established and evolving areas of research. Specifically, 61 papers were submitted, by authors from 28 different countries representing a truly “wide area network” of research activity. The DCAI’22 technical program has selected 32 full papers and, as in past editions, it will be special issues in ranked journals. This symposium is organized by the University of L'Aquila (Italy). We would like to thank all the contributing authors, the members of the Program Committee and the sponsors (IBM, Indra, Dipartimento di Ingegneria e Scienze dell'Informazione e Matematica dell'Università degli Studi dell'Aquila, Armundia Group, Whitehall Reply, T.C. Technologies And Comunication S.R.L., LCL Industria Grafica, AIR Institute, AEPIA, APPIA).