This book constitutes the refereed proceedings of the 22nd International TRIZ Future Conference on Automated Invention for Smart Industries, TFC 2022, which took place in Warsaw, Poland, in September 2022; the event was sponsored by IFIP WG 5.4.The 39 full papers presented were carefully reviewed and selected from 43 submissions. They are organized in the following thematic sections: New perspectives of TRIZ; AI in systematic innovation; systematic innovations supporting IT and AI; TRIZ applications; TRIZ education and ecosystem.