This book presenting the latest thinking on Reproductive Endocrinology and Infertility is truly international as the authors hail from no less than four different continents (North America, Europe, Australia and Asia). The idea for this book was conceived during the XII World Congress On Fertility and Sterility where the unique confluence of our distinguished authors occurred in Singapore in October 1986. The authors were involved in the Pre And Post Congress Scientific Programmes which we organised. The overwhelming success of the Congress and the Pre And Post Congress Scientific Programmes prompted this book so that those unable to attend the meeting will still be able to benefit from the vast range of topics covered. This book will be a valuable addition to the knowledge in Reproductive Endocrinology and Infertility and will be useful reading for those wishing to pursue this subspecialty. The authors are indebted to Lee Foundation (Singapore) for help in the publication of this book. We would also like to thank Miss Jam Siew Fong and Miss Tang May Mey for their excellent secretarial assistance. Singapore, January 1988 Charles SANg F H Maurine Tsakok S LTan K H Chan ix 1 Hypothalamic and Pituitary Disorders in Reproduction ROGER J PEPPERELL 1 HYPOTHALAMIC AND PrruITARY DISORDERS Disorders of ovulation are present in 15 to 25% of couples with infertility.