This is the third volume of a three-volume final report, which thoroughly describes, synthesizes and analyzes the results of the four-year Integrated Research Project CIRCE – Climate Change and Impact Research: Mediterranean Environment, funded by the EU 6th Framework Programme. Conducted under the auspices of the National Institute of Geophysics and Volcanology in Rome, Italy, the study was designed to predict and to quantify the physical impacts of climate change in the Mediterranean, and to assess the most influential consequences for the population of the region.