The impact of large radio telescopes on the progress of astronomical research in the past, present and future is the subject of twelve essays, of interest to both the layman and the professional astronomer. Current research in different fields and visions of what may be achieved with future observational possibilities are found next to contributions containing historical notes on Dutch radio astronomy and the scientific highlights of a quarter-century's work with the Westerbork Synthesis Radio Telescope. Major upgrades in progress will soon turn the WSRT into a more powerful and significantly more versatile instrument. Looking further ahead, plans for a new-generation telescope, a Square-Kilometer- Array, promise enormous advances in many areas of astronomy, among them research on pulsars, on gas in the early universe and in cosmology.