This book gathers selected papers presented at the International Conference on Deep Learning, Computing and Intelligence (ICDCI 2021), organized by Department of Information Technology, SRM Institute of Science and Technology, Chennai, India, during January 7–8, 2021. The conference is sponsored by Scheme for Promotion of Academic and Research Collaboration (SPARC) in association with University of California, UC Davis and SRM Institute of Science and Technology. The book presents original research in the field of deep learning algorithms and medical imaging systems, focusing to address issues and developments in recent approaches, algorithms, mechanisms, and developments in medical imaging.