This book gathers selected high-quality research papers presented at the 2nd International Conference on Advanced Computing Applications (ICACA 2021), held virtually during 27––28 March 2021. The book is divided into four sections. These are communication and computing, signal processing and multimedia, computational intelligence and data analytics and decision computing. The topics covered are advanced communication technologies, IoT-based systems and applications, network security and reliability, virtualization technologies, compressed sensors and multimedia applications, signal image and video processing, machine learning, pattern recognitions, intelligent computing, big data analytics, analytics in bio-computing, AI-driven 6G mobile wireless networks and autonomous driving.