This book contains the proceedings of the second edition of the international Conference on Artificial Intelligence and its Applications (AIAP'21). This edition aims to bring together leading academic scientists, international researchers, and practitioners to exchange and share their experiences and research results on all aspects of Artificial Intelligence. It also provides an interdisciplinary platform for researchers, practitioners and students to present and discuss the most recent innovations, trends, and concerns as well as practical challenges encountered and solutions adopted in the fields of Artificial Intelligence. This international conference offers an opportunity to bridge the gap between the Artificial Intelligence research community and people from the industry or working in other research areas including smart cities, big data, cloud computing, social networks, and energy.