This book constitutes the refereed proceedings of the 4th International Conference on HCI in Mobility, Transport, and Automotive Systems, MobiTAS 2022, held as part of the 23rd International Conference, HCI International 2022, which was held virtually in June/July 2022.

The total of 1271 papers and 275 posters included in the HCII 2022 proceedings was carefully reviewed and selected from 5487 submissions.

The MobiTAS 2022 proceedings were organized in the following topical sections: Designing Interactions in the Mobility, Transport, and Automotive Context; Human-Centered Design of Automotive Systems; Driver Information and Assistance Systems; Studies on Automated Driving; and Micro-mobility and Urban Mobility.