This book focuses on open issues of Society 5.0, a new paradigm of a society that balances a human-centred approach and technologies based on cyber-physical systems and artificial intelligence. The book contains results of how intelligent or cyber-physical systems help to improve the quality of life in society despite new challenges. Discusses implemented breakthrough systems, models, programs, and methods that cover the following topics: biomedicine and healthcare, innovations in socio-economic systems, intelligent energetics, advances in transport systems, human-centric technologies. These approaches help to improve human society using cyber-physical systems in a dramatically changing environment. The target audience of the book are practitioners, enterprises representatives, scientists, PhD and Master students who perform scientific research on the application of cyber-physical systems towards Society 5.0.