Welcome to the proceedings of the 2010 International Conference on u- and e-Service, Science and Technology (UNESST 2010) – one of the partnering events of the Second International Mega-Conference on Future Generation Information Te- nology (FGIT 2010). UNESST brings together researchers from academia and industry as well as prac- tioners to share ideas, problems and solutions relating to the multifaceted aspects of u- and e-services and their applications, with links to computational sciences, mat- matics and information technology. In total, 1,630 papers were submitted to FGIT 2010 from 30 countries, which - cludes 223 papers submitted to UNESST 2010. The submitted papers went through a rigorous reviewing process: 395 of the 1,630 papers were accepted for FGIT 2010, while 50 papers were accepted for UNESST 2010. Of the 50 papers 8 were selected for the special FGIT 2010 volume published by Springer in the LNCS series. 27 papers are published in this volume and 15 papers were withdrawn due to technical reasons. We would like to acknowledge the great effort of the UNESST 2010 International Advisory Board and members of the International Program Committee, as well as all the organizations and individuals who supported the idea of publishing this volume of proceedings, including SERSC and Springer. Also, the success of the conference would not have been possible without the huge support from our sponsors and the work of the Chairs and Organizing Committee.