During the last two decades, the idea of Semantic Web has received a great deal of attention. An extensive body of knowledge has emerged to describe technologies that seek to help us create and use aspects of the Semantic Web. Ontology and agent-based technologies are understood to be the two important technologies here. A large number of articles and a number of books exist to describe the use individually of the two technologies and the design of systems that use each of these technologies individually, but little focus has been given on how one can - sign systems that carryout integrated use of the two different technologies. In this book we describe ontology and agent-based systems individually, and highlight advantages of integration of the two different and complementary te- nologies. We also present a methodology that will guide us in the design of the - tegrated ontology-based multi-agent systems and illustrate this methodology on two use cases from the health and software engineering domain. This book is organized as follows: • Chapter I, Current issues and the need for ontologies and agents, describes existing problems associated with uncontrollable information overload and explains how ontologies and agent-based systems can help address these - sues. • Chapter II, Introduction to multi-agent systems, defines agents and their main characteristics and features including mobility, communications and collaboration between different agents. It also presents different types of agents on the basis of classifications done by different authors.