This book presents different topics related to innovation, complexity, uncertainty, modeling and simulation, fuzzy logic, decision-making, aggregation operators, business and economic applications, among others. The chapters are the results of research presented at the International Workshop "Innovation, Complexity and Uncertainty in Economics and Business", held in Barcelona, in November 2019, by The Ibero-American Network for Competitiveness, Innovation and Development (REDCID in Spanish) and the Royal Academy of Economic and Financial Sciences (RACEF in Spanish). These papers are useful for junior and senior researchers in the area of economics and business.