This volume contains the proceedings of the Sixth International Workshop on Bovine Spongiform Encephalopathy: The BSE Dilemma, held in Williamsburg, Virginia from February 27 - March 1, 1994. Written and edited by international experts, the papers herein cover host range and pathogenesis, transmission and pathogenesis of spongiform encephalopathies, biochemistry of the spongiform encephalopathies, the pathogenesis, molecular biology and genetics, the immunohistochemistry of spongiform encephalopathies, and the public health considerations of human and animal spongiform encephalopathies.