Dramatic advances in our understanding of cancer causation have come from epidemiologic and laboratory research, particularly over the past two decades. These developments have included a broadening interest in the critical events that take place during the early stages of the dynamic multistep process leading to - vasive cancer. Increasingly, cancer epidemiologists are pursuing research into the origins and natural history of premalignant lesions, including intermediate or surrogate endpoints, a trend - celerated by the development of molecular technologies that are revolutionizing our understanding of the transformation of normal to malignant cells. There seems little doubt that this emerging knowledge will provide further insights not only into carcinogenic processes, but also into more sensitive methods of early detection and more effective means of prevention. In this book, Drs. Franco and Rohan have succeeded in prep- ing a comprehensive, timely, and critical review of the substantial progress that has been made in our understanding of cancer p- cursors. They have enlisted experts in the ?eld who have c- tributed authoritative chapters on the precursors to a wide variety of cancers,with emphasis on etiology and natural history,including the role of environmental and heritable factors that provoke normal cells to undergo malignant transformation. Epidemiologic data are linked whenever possible to molecular as well as classical cellular pathology, providing a fuller understanding of the causal events and mechanisms that initiate the carcinogenic process.

Foreword by: J.F. Fraumeni