Each chapter will consist of basic statistical theory, simple examples of S-PLUS code, more complex examples of S-PLUS code, and exercises. All data sets will be taken from genuine medical investigations and will be made available, if possible, on a web site. All examples will contain extensive graphical analysis to highlight one of the prime features of S-PLUS. The book would complement Venables and Ripley (VR). However, there is far less about the details of S-PLUS and probably less technical descriptions of techniques. The book concentrates solely on medical data sets trying to demonstrate the flexibility of S-PLUS and its huge advantages, particularly for applied medical statisticians.