Undergraduate research in the sciences plays a critical role in both the overall education of a student and in preparing a student to go on to graduate work in the sciences. Furthermore, pedagogical research shows that early and sustained involvement in research activities benefits the student far more than either a senior year research experience or a single summer research experience. This guide is aimed at faculty setting up an undergraduate research program and includes coverage on recruiting first-year students, designing suitable projects that can be sustained throughout the undergraduate experience, and how to fully integrate student research activities with broader educational goals that will provide them with meaningful skills for their future.