This book highlights the latest advances, innovations, and applications in the field of structural and geotechnical engineering, as presented by leading international researchers and engineers at the 2nd Eurasian Conference on OpenSees—Open System for Earthquake Engineering Simulation (EOS), held in Turin, Italy, on July 7–8, 2022. The conference was meant to give an overview on the latest developments made with the OpenSees framework as well as to present research and practical outcomes in which OpenSees plays an important role. Conference topics cover cutting-edge applications of OpenSees in the field of structural and geotechnical engineering, the development of new elements and materials, and also the development of new pre- and post-processors. The contributions, which were selected by means of a rigorous international peer-review process, present a wealth of exciting ideas that will open novel research directions and foster multidisciplinary collaboration among different specialists.