This book constitutes the refereed proceedings of the 15th International Conference on Practical Applications of Scalable Multi-Agent Systems, PAAMS 2017, held in Porto, Portugal, in June 2017. The 11 revised full papers, 11 short papers, and 17 Demo papers were carefully reviewed and selected from 63 submissions. The papers report on the application and validation of agent-based models, methods, and technologies in a number of key application areas, including day life and real world, energy and networks, human and trust, markets and bids, models and tools, negotiation and conversation, scalability and resources.