This open access book analyzes the regulation and governance of gene editing in the global agrifood system as applications of gene editing, regulations and the intellectual property landscape continue to evolve. The primary focus of the manuscript is the dynamic interactions between regulatory frameworks and agricultural applications of gene editing in plant breeding. The goal is to give readers a holistic perspective on why the status of gene editing in agricultural applications is in a state of flux in some jurisdictions (e.g., the European Union) while more settled in others (e.g., Canada). Readers are provided with a clearer picture of what the future might hold for the use of gene editing in agriculture as a means to address food insecurity as the climate crisis grows and amid global geopolitical and economic turbulence.