This book presents economic research on global paradigm shifts after the COVID-19 crisis. It explores some expected deep and long-lasting changes that are building up a “new normal”. Featuring select contributions presented at the 2021 International Conference of Economic Scientific Research - Theoretical, Empirical and Practical Approaches (ESPERA), this book explores topics such as digitalization and digital sovereignty, workforce management, virtual training, digital currency, de-carbonization in production processes, supply chains, cybersecurity, automation, artificial intelligence, machine learning, Internet of Things and blockchain technologies.