This monograph is devoted to heterocyclization of aliphatic and aromatic a,ss-unsaturated carbonyls with various binucleophiles. These reactions produce partially hydrogenated nitrogen-containing heterocycles that are interesting due to their significant role in biological processes. They can be used in conjunction with combinatorial high throughput methods that involve microwave-assisted and ultrasonic-promoted reactions. The monograph is a comprehensive review of the known literature data devoted to the reactions of a,ss-unsaturated ketones, their synthetic equivalents and precursor. It is intended for chemists working in the field of experimental syntheses and theoretical investigations of nitrogen-containing heterocycles, lecturers at university and graduate students.