Vaccination is considered one of humanity’s most transformative medical breakthroughs, with its origins tracing back to Edward Jenner’s groundbreaking smallpox vaccine in the late 18th century. Though early skepticism of vaccines was formidable, rigorous scientific investigation and countless documented successes established vaccination as a cornerstone of modern medicine. For generations, vaccination was considered one of the surest ways to prevent death and suffering from infectious diseases, fundamentally reshaping global public health outcomes. However, advances in social networking and the influence of an anti-vaccination movement have reignited vaccine hesitancy on a scale not seen since the pre-modern era. Empowering healthcare providers with the skills to engage in meaningful dialogue with patients and the community about vaccines is paramount to addressing vaccine hesitancy and rebuilding public trust in vaccination programs.

This comprehensive book first lays a foundation for understanding vaccine hesitancy by exploring the historical sources of mistrust in vaccines and science. Subsequent chapters highlight evidence-based approaches to cultivate communication skills and foster meaningful dialogue in patient interactions, while emphasizing empathetic practice and self-reflection in health professions trainees. Beyond theoretical foundations, it provides practical tools and strategies for addressing the most challenging aspects of vaccine communication. When these communication principles are thoughtfully applied in clinical settings, they become powerful tools for combating misinformation, dismantling deeply held misconceptions, and nurturing patient trust.