This book highlights the role of North American entomologists and health workers in developing control strategies for diseases transmitted by mosquitoes and how mosquito’s ecology determined building regulations that shaped the image of the Canal Zone towns. On the other hand, the book determines the environmental assessment of Fort Clayton, determined by the two fundamental aspects that set on the environmental impact of an urban settlement. The first one is the suitability of the site's location. The secondis the urban structure of the adopted city model and its impact on the connectivity of the surrounding forests during the twentieth century.