The uses of time in astronomy - from pointing telescopes, coordinating and processing observations, predicting ephemerides, cultures, religious practices, history, businesses, determining Earth orientation, analyzing time-series data and in many other ways - represent a broad sample of how time is used throughout human society and in space. Time and its reciprocal, frequency, is the most accurately measurable quantity and often an important path to the frontiers of science. But the future of timekeeping is changing with the development of optical frequency standards and the resulting challenges of distributing time at ever higher precision, with the possibility of timescales based on pulsars, and with the inclusion of higher-order relativistic effects. The definition of the second will likely be changed before the end of this decade, and its realization will increase in accuracy; the definition of the day is no longer obvious. The variability of the Earth's rotation presents challengesof understanding and prediction.