This book includes high-quality papers presented at 16th International Conference on Information Technology and Applications (ICITA 2022), held in Lisbon, Portugal during October 20–22, 2022. The book presents original research work of academics and industry professionals to exchange their knowledge of the state-of-the-art research and development in information technology and applications. The topics covered in the book are cloud computing, business process engineering, machine learning, evolutionary computing, big data analytics, Internet of things and cyber-physical systems, information and knowledge management, computer vision and image processing, computer graphics and games programming, mobile computing, ontology engineering, software and systems modeling, human–computer interaction, online learning / e-learning, computer networks, and web engineering.