The authors also discuss the challenges related to “health informatics” and in “e-health management”. The topics of the book include: synchronous and asynchronous telemedicine with deep discussions on e-health applications, virtual medicalassistance, real-time virtual visits, digital telepathology, home health monitoring, and medication adherence, wearable sensors, tele-monitoring hubs and sensors, Internet of Things, augmented and virtual reality as well as e-learning technologies. The scope of the book is quite unique particularly in terms of the application domains that it targets. It is a unique hub for the dissemination of state of the art research in the telemedicine field and healthcare ecosystems. The book is a reference for graduate students, doctors, and researchers to discover the most recent findings, and hence, it achieves breakthroughs and pushes the boundaries in the related fields.