The Bosco della Mesola represents one of the few remnants of coastal woodlands in Italy. A nature reserve was established in this area in 1977. No detailed checklists of the vascular flora of the nature reserve have been compiled since then. So, there was an urgent need to fill this gap. This book contains a critical updated checklist of the vascular flora in the Bosco della Mesola Nature Reserve. It also allows quantitative comparisons with a previous checklist dating back to the 1960s in order to detect temporal changes in the vascular flora over 60 years. We believe that this book represents a milestone for scientists and all people involved in nature conservation and management in this area and in similar territories in other countries. The readerships can also include high-school students and non-professional botany amateurs.