This book provides a comprehensive overview of computational intelligence methods for semantic knowledge management. Contrary to popular belief, the methods for semantic management of information were created several decades ago, long before the birth of the Internet. In fact, it was back in 1945 when Vannevar Bush introduced the idea for the first protohypertext: the MEMEX (MEMory + indEX) machine. In the years that followed, Bush’s idea influenced the development of early hypertext systems until, in the 1980s, Tim Berners Lee developed the idea of the World Wide Web (WWW) as it is known today. From then on, there was an exponential growth in research and industrial activities related to the semantic management of the information and its exploitation in different application domains, such as healthcare, e-learning and energy management.