This book aims to provide bases for reasoning on what opportunities the regenerative approaches to urban-architectural design and development can bring to our territories and living systems (environment, society, city and learning). It collects research, experiences and considerations from experts that present innovations from different contexts, especially from the Latin-Mediterranean context. The goal of this book is to provide the reader with case studies, analysis and guidelines, resulting from scientific research from academia and practice. The book collects research focused on topics that are nowadays crucial to understand how to intervene in the complicated contexts of socio-environmental emergencies. These studies are organized into seven sections, discussing from the importance of new narrative facing future environmental challenges, to the appropriate methodologies and approaches for regenerative culture with systemic view. The book closes with outputs, dreams and hopes of regenerative design: challenges and opportunities to rewrite our alliance with the environment and to move forward our relation with the socio-environmental capital.