Progress in Clinical and Biological Research, Volume 397

ENDOTOXIN AND SEPSIS

Molecular Mechanisms of Pathogenesis, Host Resistance, and Therapy

Proceedings of the Fourth Conference of the International EndotoxinSociety Held in Nagoya, Japan, October 23-27, 1996

Jack Levin, Matthew Pollack, Takashi Yokochi, and Masayasu Nakano,Editors

Recent breakthroughs in our understanding of the molecular biologyof the human immune response have lead to important advances in therecognition and treatment of sepsis. Endotoxin and Sepsis:Molecular Mechanisms of Pathogenesis, Host Resistance, and Therapycompiles the latest basic and clinical research on many aspects ofsepsis, including sepsis/SIRS. It provides researchers andclinicians with an up-to-date overview of the critical data andconcepts in this rapidly progressing field of inquiry.

Featuring contributions by researchers and clinicians from aroundthe world, this book presents papers covering a broad spectrum ofspecialized topics in the bacteriology, biochemistry, molecular andcellular interactions, pathophysiology, and pharmacodynamics ofsepsis/SIRS. It also presents information on in vivo detection andpotential new therapies that target sepsis and its cellulareffects. Specific topics covered in Endotoxin and Sepsis: MolecularMechanisms of Pathogenesis, Host Resistance, and Therapy include:
* Enzymes essential to the biosynthesis of Lipid A and theirimportance in the design of a new generation of antibiotics
* Recent breakthroughs in the understanding of the role of CD-14 incellular resistance to infection and its therapeutic implications
* The role of Interleukin 6 in endotoxin-induced inflammatoryresponse
* The molecular mechanisms responsible for endotoxin tolerance
* Unique chemical and biological features of LPS, and natural andsynthetic LPS control mechanisms.

Endotoxin and Sepsis: Molecular Mechanisms of Pathogenesis, HostResistance, and Therapy is must reading for laboratory and clinicalmicrobiologists, immunologists, and other investigators studyingbacterial endotoxins, and specialists in internal medicine. It willalso be of interest to biotechnology and pharmaceutical researchersinvolved with the development of new drugs to combat sepsis.