This volume is considered as a unique book outlining new advances in seismotectonic research of the East Mediterranean-Red Sea Region (EMRSR). The dedicated chapters will outline the region in terms of tectonic segmentation, kinematics, and possible causes of it. It will provide state of art overview along-strike variations in geometry and behavior of faulting, jog characteristics of the active tectonic zones, analysis of earthquake clustering features, crustal deformation, constraining crustal velocity fields, relationship between strain rate and seismicity, paleoseismology, as well as global and regional seismicity. There will be specific topics within the book dedicated to the probabilistic seismic-hazard assessment of the EMRSR including its crustal stress field evolution and its implications for fault mechanics, earthquake source parameters and moment tensors, and description of double-coupled earthquake focal mechanism. Also, earthquake-induced deformational structures focusing on afterslip and spontaneous aseismic slip processes will provide a complete picture for the reader about this fascinating active region. Sections documenting the stress field variations and kinematics for diffuse microseismicity will also be developed. Other cutting edge research, such as progressive failure, spatiotemporal characteristics of seismicity that depends on accurate earthquake locations, as well as relationship of global distribution to earthquake-source geometry and tectonic origin provides up to date information within the EMRSR realm. The significance of the ambient noise level and site characterization specific to EMRSR and congruence and incongruence of active tectonic zones with normal plate kinematics will be shown in illustrative sections of this new book. The book also will explore the potential relationship of seismotectonics to sustainable development as a key societal aspect of seismotectonic research in an active convergent plate margin region such as the EMRSR.