This guide is designed for systems researchers – emerging and seasoned – searching for holistic approaches of inquiry into complexity, which the Systems Sciences provide. The authors share insight into the foundations of research that are not only systematic in terms of rigor, but systemic in perspective, analysis, design, development, implementation, reporting, and evaluation. This guide also explores researcher competencies necessary to conduct sound systems research. Researchers using this guide will gain understanding of what distinguishes systems research from other types of research and why it is important in research today.