This book provides a collection of contributions by Ph.D. students and early researchers who attended the 6th AIROYoung Workshop, held in Rome (Italy) at Roma Tre University, from 23 February to 25 February 2022. The selected contributions represent state-of-the-art knowledge related to several areas of operations research, optimization, and data science. The target audience of this book is primarily composed of Ph.D. students and early or experienced researchers in optimization and operations research. However, due to its interdisciplinary content, it is of high interest to other closely related research communities. Moreover, since it contains several works involving the use of optimization and data science in real applications, it is of interest to practitioners facing complex decision-making problems in these areas.