This book provides the conceptual framework and a comprehensive guide to the principles, methods and tools for managing organizations. The authors introduce “New Knowledge” by presenting a methodology, 'The Decalogue’, that portrays a genuinely systemic approach for managing complexity in organizations and Value Chains through focusing on the management of a leverage point called constraint (Theory of Constraints) and the understanding of variation (Theory of Profound Knowledge). This systemic approach leverages the intrinsic process and project-based nature of the work of organizations. Functional hierarchy is replaced by a network-like structure, driven by the goal of the system and governed by a new design of the organization called “Network of Projects”. The transition towards the Network of Projects requires a cognitive shift in the way we view and put to good use human talent and ingenuity as well as a powerful algorithm to orchestrate and synchronize individual competencies.