Due to fundamental similarities between the yeast
Saccharomyces cerevisiae and multicellular organisms at the
molecular level, and the powerful range of experimental
tools available for this yeast, S. cerevisiae is proving an
ideal model system for studies on protein synthesis and
targeting.
The topics covered are: - Messenger RNA stability and
translation.- The translation apparatus. - Translational
control andfidelity. - Protein targeting to the
mitochondrion. - Nuclear transport. - The secretory pathway.
- Protein folding and degradation. - Protein splicing.
Modern and often novel molecular, genetic and biochemical
approaches as well as most recent data are provided. The
reader will gain a comprehensive view of the current status
of the field.