This book provides a comprehensive review of T cell vaccination which is a topic of significant interest in the field of Immunology. However, its academic value is not limited to basic research into the understanding of autoimmune T cell regulation in vivo, for the research is supported by preliminary clinical application. Indeed, T cell vaccinations have been tested in a number of promising clinical trials as a potential treatment for human auto-immune disease. T cell vaccination has thus evolved as one of the most interesting topics of immunology and translational medicine.