This book constitutes the proceedings of the 15th International Conference on Algorithmic Aspects in Information and Management, AAIM 2021, which was held online during December 20-22, 2021. The conference was originally planned to take place in Dallas, Texas, USA, but changed to a virtual event due to the COVID-19 pandemic. 
The 38 regular papers included in this book were carefully reviewed and selected from 62 submissions. They were organized in the following topical sections: approximation algorithms; scheduling; nonlinear combinatorial optimization; network problems; blockchain, logic, complexity and reliability; and miscellaneous.