In April 1455, ten-year-old Ippolita Maria Sforza, a daughter of the Duke and Duchess of Milan, was betrothed to the seven-year-old crown prince of the Kingdom of Naples as a symbol of peace and reconciliation between the two rival states. This first full-scale biography of Ippolita Maria follows her life as it unfolds at the rival courts of Milan and Naples amid a cast of characters whose political intrigues too often provoked assassinations, insurrections, and wars. She was conscious of her duty to preserve peace despite the strains created by her husband's arrogance, her father-in-law's duplicity, and her Milanese brothers' contentiousness. The duchess's intelligence and charm calmed the habitual discord between her families, and in time, her diplomatic savvy and her great friendship with Lorenzo de' Medici of Florence made her a key player in the volatile politics of the peninsula for almost 20 years.

Drawing on her letters and contemporary chronicles, memoirs, and texts, this biography offers a rare look into the private life of a Renaissance woman who attempted to preserve a sense of self while coping with a tempestuous marriage, dutifully giving birth to three children, and supervising a large household under trying political circumstances.