In the fifth installment of the popular Ghetto Girls series, Coco suffers an injury that leaves her more helpless than she could have imagined. As she relies on her best friend Deedee for love and support, their relationship grows to another level. But Deedee finds out that her friend needs her even more than she’s letting on when Coco's unsupportive mother puts her health in a precarious position. Meanwhile, Deedee has problems of her own when her uncle is named as a person of interest in a series of murders.