The second edition of Principles of Translational Science and Medicine provides an update on major achievements in the translation of research into medically-relevant results and therapeutics. Discussed in this book are biomarkers, early human trials, and networking models as well as institutional and industrial support systems and algorithms which have influenced all major areas of biomedical research over the past several years resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. This book provides a guide for biomedical scientists to establish a systematic approach to translational medicine.

*Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development

*New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies

*Details IPR issues of translation, especially for public-private-partnerships

*Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions