eHealth 2008, the First International Conference on Electronic healthcare for the twenty-first century, was held in City University, London, during September 8–9, 2008. The conference was organized as a meeting point for telecare product vendors, policy makers, government ministers, academics, clinicians and all those involved in electronic and mobile health, to examine and to share ideas contributing to the - vancement of electronic healthcare into the twenty-first century. The conference had a huge success with a large number of paper submissions. Ninety-seven papers were submitted, of which 32 were selected for presentation. Each paper was carefully reviewed blindly by a minimum of three referees from the resp- tive field. A special thanks should go to the Technical Program Committee for their hard and efficient work in the review process. In addition to the submitted contributions, the conference included a business pres- tation track with 12 invited talks by key people in the world of eHealth. The business presentation track was chaired by Sir Jonathan Michael (Deputy Director, BT Health). The success of this conference is to be credited to the contribution of many people.